We are broadly interested in applying experimental, computational, and theoretical approaches to better understand the biology and evolution of genomes.
Our work is guided by the principle that answers to complex and important problems should not be confined by rigid disciplinary boundaries. Thus, we are primarily motivated by important biological questions and use both experimental, computational, and theoretical methods in our research. Our favorite "model organisms" are yeast, dogs, and humans, each of which are uniquely poised to answer specific questions about the biology and evolution of genomes.
Our long-term goal is to address two fundamental and interrelated questions. First, what is the genetic architecture of phenotypic variation? Second, what is the mechanistic basis of evolutionary change?
Faculty Assistant: Marybeth Fedele